Increased bone resorption through the receptor activator of nuclear factor kappa (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) system and upregulation of inflammatory cytokines are considered important mechanisms for osteoporosis in non-alcoholic fatty liver disease (NAFLD) and viral hepatitis. Here, TNFRSF11A is linked to metabolic dysfunction-associated steatotic liver disease.