SOST and osteoporosis: Widely used pharmacological treatments for osteoporosis include antiresorptive (denosumab, bisphosphate), anabolic (teriparatide, abaloparatide), sclerostin-inhibiting (romosozumab), and hormonal (hormone replacement therapy, selective estrogen receptor modulators) agents [78,227] (for a detailed review of these, see [78,227]) Regarding sarcopenia in chronic liver disease, few studies on ammonia lowering therapy reported positive effects on muscle mass increase.