SOD1 and amyotrophic lateral sclerosis: Starting from the first data reporting the presence of pathological protein aggregates of mutant SOD1 in periaxonal OL extensions in the SOD1 G93A murine model of ALS [87], signs of myelin damage have been described at a late disease stage in spinal cord ventral horn GM [88] and WM [89], as well as in upper structures of the brain [90,91].