OPTN and amyotrophic lateral sclerosis: In this respect, genetic ablation of OPTN in the whole body or specifically in OLs or microglia, but not in MNs and astrocytes, has been recently shown to induce progressive axonal pathology and myelin abnormalities in the mouse spinal cord, and consequent hindlimb disability, resembling those found in ALS patients at early stages of the pathology [109].