In the current systematic review, which investigated the genetic polymorphisms associated with BED, we found 11 polymorphisms of 9 genes that showed significant associations with BED: 5-HTTLPR (5-HTT), Taq1A (ANKK1/DRD2), A118G (OPRM1), C957T (DRD2), rs2283265 (DRD2), Val158Met (COMT), rs6198 (GR), Val103Ile (MC4R), Ile251Leu (MC4R), rs6265 (BNDF), and Leu72Met (GHRL). The gene discussed is COMT; the disease is X-linked cone dysfunction syndrome with myopia.