In order to sidestep any reduction in replication and oncolytic capacity, Shaw et al. used a gutted (helper-dependent) adenovirus to deliver various cytokine payloads in combination with replication competent oncolytic adenovirus and HER2 specific CAR T. Among the candidate cytokines IL2, IL7, IL-12p70, IL15, and IL2, expression of IL-12p70 was found to potentiate CAR T efficacy in a xenograft model of head and neck squamous cell carcinoma [47]. The gene discussed is IL2; the disease is head and neck squamous cell carcinoma.