Adenovirus encoding the murine cytokines increased CD80 and CD86 expression on tumour resident macrophages and dendritic cells, upregulated CXCL10 production in the tumour, and was associated with higher levels of infiltrating CD4 CAR T, and CD4 and CD8 endogenous T cells; all of which contributed to increased tumour control in the combination arm [100]. The gene discussed is CD4; the disease is neoplasm.