PD-1/PDL1-based-ICIs including nivolumab and pembrolizumab have demonstrated their efficacy in advanced non-small cell lung cancer (NSCLC), and are currently given in this setting in monotherapy (in first-line treatment in case of high expression of PD-L1 in immunohistochemistry (IHC) for pembrolizumab, or in second-line setting), or in combination with chemotherapy in first-line treatment [1,2,3,4]. Here, CD274 is linked to non-small cell lung carcinoma.