Although RNA-binding protein abnormalities cannot account for all sporadic ALS cases, RNA binding proteins such as TARDBP, FUS, TAF15, EWSR1, HNRNPA1, HNRNPA2B1, MATR3, and TIA1 are strongly linked with sporadic ALS [17,24,77,89,90,91,161,162]. This evidence concerns the gene PTBP1 and amyotrophic lateral sclerosis.