A number of paraspeckle-enriched RNA-binding proteins, including SFPQ, FUS, EWSR1, TAF15, TARDBP, SS18L1, and HNRNPA1, are mutated in familial cases of ALS as well as other neurodegenerative diseases [17,24,141,142,143,144]. Here, EWSR1 is linked to amyotrophic lateral sclerosis.