ALS-associated poly-GR and poly-PR DPR interact with paraspeckle components such as HNRNPF, RNRPH1, HNRNPM, SFPQ, NONO, FAM98, RBM14, and MATR3 as well as NEAT1 non-coding RNA [138,151]. Here, SFPQ is linked to amyotrophic lateral sclerosis.