The higher incidence of “pre-leukemic” mutations in men with AML was also highlighted by Metzeler et al. who showed that mutations in RUNX1, ASXL1, SRSF2, STAG2, and BCOR genes were more prevalent in men compared to women in a cohort of 664 AML patients [33]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.