The higher incidence of “pre-leukemic” mutations in men with AML was also highlighted by Metzeler et al. who showed that mutations in RUNX1, ASXL1, SRSF2, STAG2, and BCOR genes were more prevalent in men compared to women in a cohort of 664 AML patients [33]. Here, ASXL1 is linked to acute myeloid leukemia.