U2AF1 and myeloid neoplasm: These results have been associated with reproducible sex-related differences in the genomic landscape of patients with myeloid neoplasms demonstrating that men have higher incidence of mutations in high-risk genes such as ZRSR2, U2AF1, SRSF2, and ASXL1. Despite that various hypotheses have been developed including the X-chromosome inactivation hypothesis, the different metabolism of cytidine analogues, alterations in the primitive cells’ compartment and implication of hormonal receptors, these differences remain not well understood.