The analysis of the next generation sequencing data of 227 patients with MPN revealed that men have a higher number of non-MPN-specific somatic mutations and higher incidence of one or two mutations in genes such as ASXL1, IDH1/2, U2AF1, SRSF2 and EZH2 [6]. This evidence concerns the gene EZH2 and myeloproliferative neoplasm.