The relationship between HDAC6 and ABCB1 was reported by Cheng et al., in which HDAC6 could upregulate the expression of ABCB1 through the upregulation of interleukin (IL)-8, causing significant drug resistance to doxorubicin in osteosarcoma cells [63]. The gene discussed is ABCB1; the disease is osteosarcoma.