HMOX1 and acute lung injury: It was found that during Acute Lung Injury induced by LipoPolySaccharide (LPS), TRIM8 expression increases in a time-dependent manner, enhancing inflammation and oxidative stress via the inactivation of p-AMPKα, while TRIM8 knockdown relieved inflammation by regulating Nrf2 signaling and Heme Oxygenase-1 (HO-1) expressions [67].