GZMB and osteosarcoma: Interestingly, transcriptome analysis of cancer cell lines (human osteosarcoma U-2OS and cervical carcinoma HeLa cells) transfected with GRβ expression vector showed that GRβ modulates the expression of several anti-apoptotic genes, such as B-cell lymphoma 2 (BCL2), and this independently of GRα [13,14].