Moreover, GRβ overexpression in HTC116 cells, a human colorectal carcinoma cell line lacking endogenous GRα, upregulated the mRNA expression of S100P, which is commonly associated with the progression of metastasis [13] while downregulating the expression of other genes associated with cell migration and metastasis, such as tenascin C (TNC) and laminin A4 (LAMA4) [13]. Here, TNC is linked to colorectal carcinoma.