Nuclear receptors such as retinoic acid receptors, liver X receptors, peroxisome proliferator-activated receptors (PPARs), farnesoid X receptors (FXRs), and pregnane X receptors form heterodimers with the retinoid X receptor and modulate gene expression in response to dietary ligands such as cholesterol, fatty acids, and bile acids, all of which are linked to cholesterol metabolism and NAFLD [93,94]. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.