The inflammatory response that is induced in NASH causes circulating monocytes to migrate to the liver, where they—together with the liver resident Kupffer cells—contribute to HSC activation and fibrosis by producing cytokines such as TGFβ, PDGF, TNF, interleukins, and chemokines [14]. The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.