Moreover, in an effort to provide “a potential nosology for precision-medicine strategies in DLBCL”, Schmitz et al. reported the discovery of four principal “genetic subtypes of DLBCL with distinct genotypic, epigenetic, and clinical characteristics”, namely, MCD (characterized by co-occurrence of MYD88L265P and CD79B mutations), and N1 (based on NOTCH1 mutations) which are ABC-dominated, the EZB (rich in EZH2 mutations and BCL2 translocations) which is mostly GCB, and the BN2 (harboring BCL6 fusions and NOTCH2 mutations) consisting of ABC, GCB and unclassified cases [8]. This evidence concerns the gene NOTCH1 and aneurysmal bone cyst.