More so, while acknowledging the poor prognostic peculiarity of DHL/THL and the benefits associated with inclusion of MYC, BCL2, and BCL6 gene translocation and protein expression in routine clinical work-up of patients with suspected DLBCL, little is known about the differential ethno-specific or geo-regional signature of DHL/THL. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.