CD40LG and dengue disease: This discrepancy suggests differences in the structural characteristics of the three flaviviruses that affect the induction of antibodies against the most conserved sites in E. Even in the case of dengue virus infections, however, a direct quantitative comparison of IgM with all antigens in one standardized assay allowed an unambiguous differentiation between infections with these viruses, and in most instances even the identification of the infecting dengue serotype.