Fan and collaborators [90] determined the positive membranous immunostaining of TrKA in most OSA cells in 66% (10/15) of primary bone lesions and in 75% (9/12) of spontaneously occurring canine OSA metastases, suggesting that TrKA serves as a potential therapeutic target of both primary and metastatic canine OSA [90]. This evidence concerns the gene NTRK1 and obstructive sleep apnea syndrome.