Studies with transplant patients with DCM have reported a significant decrease in cardiac angiogenic factors [such as vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 1 (VEGFR1)] expression and lower capillary density [11], suggesting downregulation of cardiac angiogenesis during DCM phenotype. The gene discussed is FLT1; the disease is familial dilated cardiomyopathy.