Ragusa et al. [229] had previously discovered the interaction between miR-671-5p and the EGFR signaling pathway and its roles in chemoresistant CRC cell lines, so Xiong et al. [201] proposed that the downregulation of hsa_circ_0048234 could increase EGFR signaling and promote CRC resistance by targeting miR-671-5p. This evidence concerns the gene EGFR and colorectal carcinoma.