The lncRNA Plasmacytoma Variant Translocation (PVT1) was associated with 5-FU resistance in human CRC tissues and cells, through inhibition of apoptotic cell death and upregulation of Multidrug Resistance Protein 1 (MRP1), P-gp, mTOR, and apoptosis regulator Bcl-2 [199]. The gene discussed is PGP; the disease is colorectal carcinoma.