Due to DOX being one of the available cytotoxic drugs which target the TOP2α subunit of type IIA topoisomerases [16], Silva-Fisher et al. further investigated how overexpression of RAMS11 promoted resistance in the CRC cell lines [283], determining that RAMS11 overexpression increased TOP2α protein expression in CRC cell lines, which lead to cell lines becoming resistant to not only DOX but other chemotherapeutic drugs which also target TOP2α in their mode of action [283]. This evidence concerns the gene TOP2A and colorectal carcinoma.