KCNQ1OT1 and colorectal carcinoma: In another study, Zheng et al. showed that the lncRNA KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) is significantly upregulated in cisplatin resistant CRC cells, while cisplatin sensitivity was enhanced if KCNQ1OT1 was silenced [263].