FBXW7 and colorectal carcinoma: In the study by Ding et al. [278], it was proposed that upregulation of miR-223 promotes DOX resistance in CRC cells via regulation of EMT, by targeting a tumor suppressor F-box and WD repeat domain containing 7 (FBXW7), as evidenced by downregulation of the epithelial marker E-cadherin and upregulation of the mesenchymal marker Vimentin.