Apart from the interaction between the lncRNA and miRNA, the miRNA was shown to also interact with a disintegrin and metalloprotease metallopeptidase domain 17 (ADAM17), the mRNA and protein levels of ADAM17 being upregulated in the OXA resistant tissues and cells, which hinted to its role as a mediator in CRC chemoresistance [258]. Here, ADAM17 is linked to colorectal carcinoma.