FOXO3 and colorectal carcinoma: In another study, in vivo and in vitro investigation showed that increased expression of miR-153 was not only responsible for increased CRC growth but also gave rise to OXA and cisplatin resistance by blocking the Forkhead transcription factor ‘Forkhead box O3a’ (FOXO3a), responsible for a variety of processes, particularly initiation of the apoptotic pathway [241].