The Epithelial Growth Factor Receptor- Rat Sarcoma- Mitogen Activated Protein Kinase (EGFR-RAS-MAPK), Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor (VEGF/VEGFR), Phosphatidylinositol-4,5-bisphosphate 3-kinase/Protein Kinase B (PI3K/AKT), WNT/β-catenin, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and Notch1 signaling pathways seem to be the most important signaling pathways involved in chemoresistance of CRC cells [19,20]. The gene discussed is VEGFA; the disease is colorectal carcinoma.