At an IC50 value of 16 nM, which is close to the Kd values for RARα, β and γ, AGN194310 treatment led to growth arrest and cell death of DU145, LNCaP and PC3 PCa cell lines cultured in flasks (which contain a high proportion of non-CSC-like cells) [74]. This evidence concerns the gene RARA and posterior cortical atrophy.