In this study, we identified the synergistic effect of combining gp120-binding protein mD1.22 and gp41-binding antibody D5 scFv on inhibition of infection by divergent HIV-1 strains, including laboratory-adapted strains, primary HIV-1 isolates, T20-resistant HIV-1 strains, and AZT-resistant HIV-1 strains. The gene discussed is ITIH4; the disease is infection.