ITIH4 and HIV-1 infection: These results demonstrated that gp41-targeting antibody D5 scFv in combination with gp120-binding protein mD1.22 exhibited a synergistic effect on inhibition of HIV-1 infection, while D5 scFv could enhance mD1.22-mediated HIV-1 inactivation effect, suggesting a good potential to develop this combinatorial strategy for treatment of HIV-1 infection.