The mechanisms by which hypoxia is capable of producing a suppression of the immune system are widely known: either by favoring the expression of PD-L1, V-Domain Ig Suppressor T Cell Activation (VISTA), and CD47 in hypoxic tumor cells, that inhibits T cells and prevents recognition by macrophages; as well as inducing autophagy [37,38] or MIC shedding [39]. The gene discussed is CD274; the disease is neoplasm.