PTEN and glioblastoma: ceRNA networks between miRNAs and mRNAs were first described in the context of the somatic genomic landscape of GBM, where 133 miR:mRNA associations defined a putative miR regulatory network that was associated with GBM signature genes PDGFRA, EGFR, NF1, and PTEN, and the bulk GBM transcriptional subtypes [70].