PML deficiency in HCV-transgenic (HCVtg) PML-deficient (PML−/−) mice enhanced susceptibility to tumor induction by diethylnitrosamine (DEN)/phenobarbital (PB) treatment compared to WT, HCVtg, and PML−/− mice groups by enhancing hepatocyte proliferation [38]. The gene discussed is PML; the disease is neoplasm.