It is known that the sequence of murine and human EGFR are 88% identical and that EGF binding induces phosphorylation of EGFR in both species [114]; however, further studies are needed to assess whether species-related differences in EGFR indeed contribute to the lower infection efficacy in NTCP-based murine hepatocytes, both in vitro and in vivo. The gene discussed is EGFR; the disease is infection.