The involved KEGG pathways were mainly the Alzheimer disease (hsa05010), serotonergic synapse (hsa04726), the calcium signaling pathway (hsa04020), the PI3K-Akt signaling pathway (hsa04151), dopaminergic synapse (hsa04728), the neurotrophin signaling pathway (hsa04722), the notch signaling pathway (hsa04330), and cholinergic synapse (hsa04725) (Figure 6B). This evidence concerns the gene AKT1 and Alzheimer disease.