Since it has been shown that inhibition of STAT3 signaling leads to CLL cell death [15] and that the antitumor effects of shikonins are mediated by STAT3 inhibition [16,17], the expression of pSTAT3 in IBS- and MBS-treated BCL1 and JVM-13 cells was analyzed by flow cytometry. Here, STAT3 is linked to B-cell chronic lymphocytic leukemia.