Treatment of JVM-13 cells with IBS and MBS at a concentration of 2 μg/mL significantly attenuated the percentage of Mcl-1-expressing cells and significantly enhanced the percentage of cells that expressed the pro-apoptotic molecule Noxa, even at a lower concentration of 1 μg/mL (Figure 2c). This evidence concerns the gene PMAIP1 and irritable bowel syndrome.