FLT3 and acute myeloid leukemia: It is worthy of note that although NOX4 expression has been previously described downstream of FLT3-ITD in AML cells [28,54,55], our transcriptional analyses, using three different technologies (microarrays, RNA-seq and qRT-PCR), established that its mRNA expression is lacking from all AML subtypes, including FLT3-ITD.