The IGF-1 pathway is known to mediate resistance to radiotherapy in several types of cancers and has been suggested as a potential target to potentiate radiation therapy [40,41];perturbation of the insulin/IGF-1 phosphatidylinositiol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway in normal tissues has been associated with short- and long-term radiation-induced vascular dysfunction and death [21,42,43,44,45]. This evidence concerns the gene IGF1 and cancer.