GNAQ and intrahepatic cholangiocarcinoma: Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ, encoding Gαq),GNAS, and GNA14 (encoding Gα14) mutations were also found in hepatic small vessel neoplasm and intrahepatic cholangiocarcinoma in the liver, although their roles have not been elucidated [9,10].