Meanwhile, PKD2 knockdown in lung adenocarcinoma cell lines significantly reduced the expression of mesenchymal markers (N-cadherin, vimentin) and the transcription factors that stimulated EMT (Twist, Snail), along with inhibiting cell migration, invasion, and proliferation, indicating that PKD2 promotes the EMT and metastatic potential of lung adenocarcinoma [110]. This evidence concerns the gene TWIST1 and lung adenocarcinoma.