PRKD3 and neoplasm: Mechanistic studies indicated that depletion of PKD3 blocked the secretion of MMP-9 and several tumor-promoting cytokines, such as IL-6, IL-8, and GROα, without altering their mRNA levels [87] and that inducible depletion of PKD3 in a subcutaneous xenograft model decreased levels of intratumoral GROα in mice [87].