PRKD3 and Familial prostate cancer: However, in this study, the authors commented that depletion of PKD2 or -3 had no effect on VEGF secretion from prostate cancer cells or mast cells; instead, a role of PKD2 and PKD3 on the secretion of stem cell factor and chemokine ligand 5 and C-C motif chemokine 11 expression was implicated in the response [47].