A later study by the same group showed that overexpressing PKD1 in prostate, breast, and colon cancer cell lines led to accumulation of cells in G1 phase, which may be mediated through the direct phosphorylation of all three cell-division cycle 25 proteins (Cdc25s) (A, B, and C) by PKD [60]. This evidence concerns the gene PKD1 and malignant colon neoplasm.