ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: For example, in human myeloid leukemia cells, PKD2 is constitutively tyrosine-phosphorylated by the oncogenic Bcr–Abl fusion protein, a driver of chronic myeloid leukemia and a mediator of Bcr–Abl-induced NF-κB activation [72].