HLA-C and neoplasm: Furthermore, altered levels of pro- and anti-apoptotic proteins, such as B cell lymphoma 2 (BCL2) proteins and inhibitor of apoptosis proteins (IAP) [191,192] as well as downregulation of MHC proteins [193], recruitment of Tregs and myeloid-derived suppressor cells (MDSC) [194,195] lead to the development of an immunosuppressive tumor microenvironment (TME) [196,197].