Their highly specific recognition of malignant or infected cells is based on the interaction of a compatible membrane-bound T cell receptor (TCR) with short peptide motifs related to tumor-associated antigens (TAA) or viral proteins that are presented on the MHC or human leukocyte antigens (HLAs) by antigen presenting cells as well as other nucleated cells [41,42,43]. This evidence concerns the gene HLA-C and neoplasm.