NOX1 and obesity due to melanocortin 4 receptor deficiency: Platelet PDI was upregulated in obesity (25% higher in class 2 obesity vs. healthy weight) (Figure 6B), while Nox-1 was increased in individuals that presented with obesity (75% higher in class 2 obesity vs. healthy weight), high blood pressure (25% higher in high blood pressure stage 2 vs. normal) or central obesity (25% higher in central obesity vs. normal) (Figure 6E–G).