After establishing that the co-inhibition of PDI and Nox-1 is a potential strategy to inhibit platelets with minimal bleeding, we evaluated if the expression levels of these proteins would be correlated with conditions of increased cardiovascular risk, i.e., obesity, central obesity, high blood pressure and hyperglycaemia, where elevated platelet function has been noted [32,33]. This evidence concerns the gene NOX1 and obesity due to melanocortin 4 receptor deficiency.