As evidenced by children with underlying immunodeficiency, immune control of mycobacteria is dependent upon cell-mediated immunity (Mtb-specific T lymphocytes, dendritic cells, Toll-like receptors, γ-interferon (IFNγ), Tumor Necrosis Factor-α (TNFα), and interleukin), as well as macrophages and neutrophils [37]. This evidence concerns the gene TNF and immunodeficiency disease.