Retrospective studies from a global multicenter network of patients and a national database of U.S. oncology practices have reported patients with ALK-rearranged NSCLC tumors to be relatively refractory to single-agent ICI therapy (median progression-free survival of ~2–3 months) [11,35], indicating that the clinical benefit of ICI in ALK-rearranged NSCLC is modest to poor. The gene discussed is ALK; the disease is non-small cell lung carcinoma.