None of the genetic studies performed in ≤55 EOCRC patients shown in Table 1 identified biallelic pathogenic variants in the MMR genes (total number of ≤55 CRC patients where MMR genes were analyzed: 6359), suggesting that the prevalence of CMMRD among EOCRC is extremely low, and/or that the <50 or ≤55 age cutoff defined as inclusion criterium is too high to select for CMMRD cases. The gene discussed is MRC1; the disease is colorectal carcinoma.