While our group found no predicted pathogenic RPS20 variants among 473 familial/EOCRC cases [38], a recent study identified a splicing variant, c.177 + 1G>A, in a family with four CRC-affected members (ages at diagnosis: 38–61), all of them carriers or obligate carriers of the RPS20 variant [39]. Here, RPS20 is linked to colorectal carcinoma.