RPS20 and colorectal carcinoma: Subsequently, exome sequencing analyses performed on 863 EOCRC patients led to the identification of a disruptive RPS20 variant (p.Leu61Glufs*11) in a 39 year-old individual with metachronous CRC, and a predicted pathogenic missense variant (p.Val154Leu) in a patient diagnosed with CRC at age 41.