Due to the novelty and rarity of RNF43, reported studies using multigene panel testing in EOCRC did not include RNF43. Nevertheless, access to CanVar (https://canvar.icr.ac.uk/ (accessed on January 2021)), a public database that gathers whole-exome and -genome sequencing information of 1006 CRC patients diagnosed before age 60 years, showed that six patients carried rare germline missense variants, none of which was predicted pathogenic (REVEL > 0.5). Here, RNF43 is linked to colorectal carcinoma.