MECP2 and stroke disorder: Moreover, Yang et al. used rabies virus glycoprotein-circSCMH1-extracellular vesicles to selectively deliver circSCMH1 to the brain; circSCMH1 binds to methyl-CpG binding protein 2 (MeCP2) and blocks MeCP2 transporting to the nucleus, promoting the expression of downstream target genes of MeCP2, enhancing neuronal plasticity, and effectively improving the functional recovery after stroke in mice and monkeys [112].