Based on the transcriptome data from the GEPIA database [43], seven hub proteins identified in this study were over-expressed in colon tumors at the transcriptional level, and MRPL15, 30, and 37 were significantly over-expressed in colon tumor samples (a two-fold change with p-value < 0.05 as a cut off) (Figure 6A). This evidence concerns the gene MRPL15 and colonic neoplasm.