Additionally, TNF-αinduces the release of ATP, and the ATP-stimulated Ca2+ channel P2Y2 receptor induces tumor growth and invasion of MDA-MB-231 cells (estrogen receptor-negative), but MCF-7 (estrogen receptor-positive) cells, which has a low metastatic feature, induces less release of ATP and reveals low P2Y2 receptor activation [82]. Here, ESR1 is linked to neoplasm.