Ca2+ signaling through IP3R in the nucleus plays a critical role in inducing angiogenesis in breast cancer cells (MDA-MB-468) and regulates angiogenesis-related genes, including early growth response-1, C-X-C motif chemokine ligand 10 (CXCL10), C-C motif chemokine ligand (CCL)-2, and dentin matrix acidic phosphoprotein 1 (DMP1) [132]. Here, ITPR1 is linked to breast cancer.