We addressed this question by blocking in the tumor cells two major signaling components that are of high importance to cancer: (1) the Ras protein, which is stimulated typically by receptor tyrosine kinases (RTKs) [55,56,57], and (2) the heterotrimeric G protein Gαi that mediates signaling using many G protein-coupled receptors (GPCRs) [58,59,60]. The gene discussed is NTRK1; the disease is cancer.