These inflammation-driven CAFs secrete metastasis-promoting factors that elevate the dispersion, scattering, and migration of breast cancer cells via activation of tumor cell receptors that signal through Ras proteins and via Gαi proteins; the latter receptors were identified as the chemokine receptors CCR2, CCR5, and CXCR1/2. This evidence concerns the gene CCR5 and breast carcinoma.