CCL5 and neoplasm: Therefore, the data provided above suggest that CCL2, CCL5, and ELR + CXC chemokines—that are upregulated in the CM of the inflammation-driven CAFs (Figure 5(C2))—are the factors that were released by the inflammation-driven CAFs and promoted tumor cell migration by activating their cognate Gαi-stimulating receptors (Figure 11).