We also found that the number of PD-L1+ cells was significantly lower in p53-GOF and p53-LOF SCCs compared to p53-WT SCCs (Figure 3F and Figure S3D), which may explain the lack of a robust increase in PD-L1 expression in SCCs compared to papillomas noted above (Figure 3D,E). This evidence concerns the gene CD274 and papilloma.