Indeed, many individual targeted studies have reported dynamic regulatory SUMOylation events on key factors involved in almost all stages of the IFN response, including sensing virus infections (RIG-I, MDA5, cGAS) [24,25,26], signaling leading to IFN transcription (MAVS, STING, IRF3/7) [25,26,27,28], signaling leading to ISG transcription (STAT1) [29], or activity of ISGs directly (PML, PKR, SAMHD1, MxA/B, ADAR1) [30,31]. Here, IFNA1 is linked to viral infectious disease.