CFTR and renal agenesis: The clinical management of men affected by CBAVD without renal agenesis must include CFTR analysis, which should be based on two steps: (1) a targeted panel of the most commonly known CF-causing mutations in the Caucasian ethnic group, including R117H and 5T allele; (2) a comprehensive screening of CFTR for rare point mutations and large rearrangements, when none or only one single mutation has been identified by the first step.