A combined therapy of ablative radiation dose (20 Gy) with a fusion protein of humanized anti-CEA (carcinoembryonic antigen) and human IL-2 (M5A-IL-2) in a transgenic murine breast and colon tumor model expressing human CEA, had significant antitumor affects as compared with RT alone [148]. This evidence concerns the gene CEACAM5 and colonic neoplasm.