In line with this, TERT inhibition via BIBR1532 was shown to increase the percentage of Annexin-V+ and Annexin-V+/Propidium Iodide+ cells, as well as increase Caspase 3 activity in a human pre-B acute lymphoblastic leukaemia cell line [24]. This evidence concerns the gene ANXA5 and acute lymphoblastic leukemia.