IL6 and neoplasm: For instance, αSMA-expressing and FAP-positive myofibroblastic CAFs (myCAF) were adjacent to the tumor, while “inflammatory” CAFs (iCAF) with reduced αSMA expression were found in the dense stroma and secreted IL-6, CXCL-1, and CXCL-2 through the activation of IL-1α-Janus kinase (JAK)-STAT signaling [116,119].