In this context, additional CAF subtypes were identified [125]: CAF-1 cells expressing FSP-1, which promote metastatic colonization of tumor cells through tenascin- and VEGF-mediated angiogenesis [126]; and CAF-2 cells that are characterized by the presence of αSMA, neural/glial antigen 2 (NG2), and PDGFRβ [127]. Here, ACTA1 is linked to neoplasm.