Regarding the role of NLPR3 in the adipose tissue of obese mice, the pharmacological inhibition of the NLRP3 inflammasome has been demonstrated to improve lipid and glucose handling, reducing cytokine secretion, fibrosis and adipose tissue remodeling, suggesting a potential therapeutic role for metabolic alterations associated to obesity [160]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.