The insulin-induced phosphorylation of Akt in the skeletal muscle of NLRP3−/− HFD-fed mice was similar or potentiated compared to their littermate controls [5,6], suggesting that the NLRP3 inflammasome can mediate obesity-associated deleterious signals in the skeletal muscle and contribute to obesity-induced inflammation and IR [5]. This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.