It has been reported that HFD feeding stimulates IL-1 type I receptor (IL-1R), mediating intracellular inflammatory signaling in murine skeletal muscle, suggesting that the IL-1R type I/Myeloid differentiation primary response 88 (MyD88)/NF-κB signaling pathway is involved in the skeletal muscle inflammatory response in a diet-induced obesity model [49]. This evidence concerns the gene MYD88 and obesity due to melanocortin 4 receptor deficiency.