ACO1 and Iron deficiency anemia: Under iron deficiency, IRP1 and IRP2 have a higher affinity to IRE regions, and their binding leads to the inhibition of FTH and FTL translation and protects TRFC against degradation Furthermore, observed increase in TFRC mRNA after starvation support this conclusion as it has been reported that activation of IRP leads to upregulation of the receptor as IRP protects TFRC mRNA from degradation [35].