INS and obesity due to melanocortin 4 receptor deficiency: For this reason, in the present study, we addressed whether in our [18F]-FDG/PET dataset, carrying the rs17782313-C allele could have affected the central findings, in parallel to the findings of Tschritter et al. As in the aforementioned study, also in our dataset presence of the obesity risk allele rs17782313-C did not lead to differences in BMI or insulin sensitivity (M value).