In a previous study the Tübingen group has reported that carriers of the obesity risk allele rs17782313-C had blunted insulin-stimulated cerebrocortical theta activity compared to non-carriers even though there was no difference in the insulin sensitivity index (M value) in the hyperinsulinemic euglygemic clamp between the groups [7]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.