Gain-of-function mutations in human TRPV3 can lead to the Olmsted syndrome, which is characterized by a severe periorificial and palmoplantar keratoderma without affecting cerebral functions [54,55], suggesting a lack of function for TRPV3 in the brain [53]. This evidence concerns the gene TRPV3 and epidermolytic palmoplantar keratoderma, 1.