NFAT5 and rheumatoid arthritis: In previous studies, since complete loss of NFAT5, specifically deletion of exons 6 and 7, results in late gestational or perinatal lethality [23], NFAT5-Het mice have mostly been used for in vivo studies, such as hippocampal inflammation [24], hypothalamic inflammation [25], and rheumatoid arthritis [17] studies.