Three days after PT, the total number of PGC-1α-immunopositive neurons decreased by 10%, and the number of neurons with high nuclear PGC-1α immunoreactivity decreased by 70% (p < 0.05) compared to the first day after stroke modeling in the Stroke + Saline group (Figure 7A,B, Figure S28). Here, PPARGC1A is linked to stroke disorder.