In the Stroke + Mexidol group, 24 h after ischemia induction, the level of PGC-1α expression in the penumbral tissue was comparable to that in the control animals, which was 30% higher than the PGC-1α expression level in the Stroke + Saline group (p < 0.01; Figure 6A). This evidence concerns the gene PPARGC1A and Stroke.