In the Stroke + Mexidol and Stroke + Semax groups, within 24 h after ischemia, the number of PGC-1α-immunopositive neurons in the penumbra remained on a level comparable to that of the Control group but 15% higher than that in the Stroke + Saline group (p < 0.05). This evidence concerns the gene PPARGC1A and ischemia.