PPARGC1A and ischemia: At Days 7 and 21 after PT in the Stroke + Saline group, the total number of PGC-1α-expressing neurons and neurons with medium nuclear PGC-1α immunoreactivity progressively decreased and, at Day 21, achieved 75% and 50% (p < 0.05), respectively, compared to Day 1 after ischemia induction (Figure 7A,B, Figure S28).