The most pronounced effects of Mexidol on the PGC-1α activity were observed over the 7 days of the course, where we observed a significant increase of 40% in the NRF1 expression level (p < 0.01), 100% in TFAM (p < 0.01), 30% in NDUFV2 (p < 0.01), 100% in SDHA (p < 0.01), 80% in VEGF (p < 0.01), and 20% in SYP (p < 0.01) compared to the Stroke + Saline group. This evidence concerns the gene NDUFV2 and Stroke.