PPARGC1A and ischemia: The putative activators of PGC-1α in the acute period of ischemia can be considered a flow of calcium ions initiated via hyperstimulation of the ionotropic glutamate receptors (NMDA and AMPA) [93] through the activation of Ca2+/CaM kinase, thereby phosphorylating and activating PGC-1α, as well as the products of necrotic cell degradation, known as damage-associated molecular patterns (DAMPs), which are recognized by the TLRs of neurons and other cells of the central nervous system [94,95].