In our stroke model, we observed a pronounced short-term PGC-1α activation, evidenced by a significant upregulation of PGC-1α-dependent proteins: NRF1, TFAM, catalytic subunits of the substrate-binding sites of the respiratory chain (NDUFV2 and SDHA), VEGF, and SYP. The gene discussed is NRF1; the disease is Stroke.