Finally, other biomarkers of endothelial dysfunction are increased in women with PCOS, such as visfatin, VEGF, matrix metallopeptidase 9 (MMP9), high-mobility group box 1, pentraxin 3, and soluble lectin-like oxidized low-density lipoprotein receptor-1 [215]. The gene discussed is MMP9; the disease is polycystic ovary syndrome.